“Do we fight to change things or do we fight to punish?” This question is posed by the Gandhi character in the award-winning film of the same name. Although no record exists of the real Gandhi uttering these words, the sentiment is one he surely would have endorsed. It was his life’s work not to punish others, but rather to change their hearts, minds, and, ultimately, their actions. The same question also must be asked when beginning to work on any therapeutic target, because

We all know the feeling of a missed opportunity, the stream of “what ifs” that flows from regret. Sometimes a window of opportunity truly does close and there is nothing left to do but cope with the emotions that fill the resulting void. But often, whether in our relationships, careers, or with regard to personal goals, we do get a second chance to get it right. If we want to give ourselves the best opportunity to get it right the next time around, it pays to focus on why we