“Do we fight to change things or do we fight to punish?” This question is posed by the Gandhi character in the award-winning film of the same name. Although no record exists of the real Gandhi uttering these words, the sentiment is one he surely would have endorsed. It was his life’s work not to punish others, but rather to change their hearts, minds, and, ultimately, their actions. The same question also must be asked when beginning to work on any therapeutic target, because

What do you consider an occasion worthy of celebration? Graduating college, getting a promotion, giving a good presentation? There are no rules for when it’s appropriate to party, but where you set the bar says something about how you feel about yourself and how you define success. On one extreme, there are some objectively successful people who, sadly, find it impossible to celebrate even great achievements because they are consumed by their perceived failures. On the other